"Capacitance measurement is a very good tool to observe the attachment of the animal cells on carriers in real time. This offers the possibility to optimise the selection of the carriers (diameter, size of the pores, kind of modification) to obtain the best conditions for the cultivated cells."
"Using the Aber Biomass Monitor for index glucose feeding of a Pichia Pastoris fermentation, we were able to increase productivity by almost 30% on a mature development stage process."
The Aber Biomass Monitor with the probe using annular electrodes can successfully replace traditional methods such as packed cell volume and viscosity for monitoring Streptomyces fermentations and gives an accurate and on-line description of the entire process. Moreover, it enables the on-line computation of the specific growth rate and thus the development of more accurate and reproducible process operational control strategies.
"The Aber Biomass Monitor is probably the best available in situ sensor for direct measurement of the viable cell density"
"We have demonstrated that using the Aber Biomass Monitor with mammalian cell cultures, monitoring the capacitance at multiple frequencies allows not only a viable cell concentration measurement but it can also provide a real time measurement of the cell size distribution. The system can provide a useful tool for process development, optimization and control"